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物种
Human分子别名
TL1; VEGI; Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth InhibitorAccession
O95150-1表达序列
Leu72-Leu251表达宿主
E.coli分子量
21kDa (Reducing)
纯度
＞95% by SDS-PAGE&RP-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
No Tag性状
Lyophilized powder缓冲体系
20mM Tris, 300mM NaCl, pH8.0溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.2022 Jul 14:13:891328. eCollection 2022.
TNF-like cytokine 1A (TL1A) is a member of the TNF and TNF receptor superfamily. TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses. TL-1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-α and IL-1α. TL1A binds with high affinity to death receptor 3 (DR3), known as TNFRSF25. Recombinant human TL1A is a 21 kDa polypeptide of 180 amino acid residues
生物活性
Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells. The EC50 for this effect is less than10ng/ml.
电泳(SDS-PAGE)
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2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
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