NRG1/Heregulin-β1 Protein, Human

浏览次数：1

货号： UA040157

大包装询价

产品介绍引用文献(0) 评论(0)

产品规格

物种

Human
分子别名

Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF
Accession

Q02297-6
表达序列

Ser177-Glu241
表达宿主

E.coli
分子量

7-8kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

PBS,pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Cell Rep. 2021 Sep 7;36(10):109656.
Cell Rep. 2021 Aug 17;36(7):109538.

背景介绍

Heregulin-β also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases. And NRG1 isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. The NRG1 receptors are membrane-spanning receptor tyrosin kinases of the ErbB family (ErbB1–4), of which the EGF receptor (ErbB1) is the most prominent representative.

生物活性
- Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The EC50 for this effect is less than 0.5ng/mL.
电泳(SDS-PAGE)
- 2μg (R: reducing condition, N: non-reducing condition).