IL-28B/IFN-λ3 Recombinant Rabbit mAb (SDT-1838-77-2)
货号： S0B3407
- 价格： ￥7,500
- 规格：
- 数量：
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宿主来源
Rabbit抗原名称
IL-28B/IFN-λ3免疫原
Recombinant Protein克隆号
SDT-1838-77-2抗体类型
Recombinant mAb抗体同种型
IgG应用
Sandwich ELISA反应种属 ?
Hu交叉反应
No cross-reactivity against IL-28A, IL-29, IL-10
纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt, 2 to 8 °C as supplied
IL28B is a newly-discovered type III interferon, with antiviral, antiproliferative, and immunomodulatory functions. Type III IFNs share homology with IL-10 and the IL-10R2 receptor subunit, leading to the speculation that these cytokines might be evolutionarily related. It was recently found that polymorphisms in IFN-lambda-4 (another type III interferon) are associated with circulating IL28B, and higher plasma IL28B are associated with higher production of antibodies to HBV surface antigen. IL28B is associated with the extent of lupus activity, in particular with active serosal and cutaneous disease. Combined treatment with IL28B and sorafenib (a small molecule multikinase inhibitor) facilitates a synergistic effect on suppressing hepatocellular carcinoma cancer growth and promoting cell apoptosis in vitro and in vivo.
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