Human PIVKA-II/DCP, His Tag

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货号： S0A6005

大包装询价

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产品规格

物种

Human
Accession

P00734
表达序列

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGEGGGGSHHHHHHHHHH.
表达宿主

HEK293
分子量

71.7 kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

0.2M PBS, pH7.4
溶解方法

Reconstitute at less than 1 mg/mL according to the size in deionized water after rapid centrifugation.
储存条件

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

背景介绍

DCP (Des-gamma carboxyprothrombin) is also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II). Prothrombin, a blood coagulation protein synthesized in liver, is converted to an active form after the 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20, 25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ-glutamyl carboxylase. Incomplete carboxylation of one or more Glu residues at any of the sites mentioned above may result in DCP and loss of coagulation function. Abnormal prothrombin elevation is more common in patients with vitamin K deficiency, warfarin therapy and hepatocellular carcinoma (HCC), so DCP can be used as a marker for HCC diagnosis. The value of this target in combination with traditional tumor marker alpha-fetoprotein (AFP) in the early diagnosis of HCC has been widely recognized. High PIVKA-II/DCP values indicate a potential risk of cirrhosis or hepatocellular carcinoma and should be followed up.This product is the recombinant human PIVKA-II /DCP protein expressed from human 293 cells (HEK293).